Takeda California uses the non-contact ATS-100 Acoustic Transfer System in various compound management liquid handling activities in support of drug discovery processes. It is widely accepted that proper quality assurance is important for accurate and efficient processes – and proper calibration of automated liquid handling instruments is a key component of such quality assurance.
This study illustrates how optimization of both liquid-handling accuracy and precision is critical to assay performance. The study was designed to examine (1) liquid-handling performance and (2) the effect of liquid-handling variability on two types of in vitro biochemical assays by making small but deliberate changes to assay volume delivery. Specifically, protein binding (streptavidin) and […]
By Bradshaw, J., Curtis, R., Parshley, R., Flumerfelt, L.
This presentation will address the difference in performance of a handheld micropipette when dispensing water versus various types of animal and human serum, as well as a serum-like dye solution. These differences are quantifiable and can be accounted for through careful experimentation and attention to physical pipetting details.
By Campbell, D., Knaide, T. - Artel, Roby, K. - Beckman Coulter
Lowering costs and reducing repeat testing are common interests in all areas of life science. Removing sources of variability from test processes reduces error leading to rework, lowers risk and increases reliability of results. One likely source of variability, which is easily controlled, is liquid handling.
Over the years, influenza has taken the lives of millions. While vaccines are helping to reduce the damage caused by the virus there is still a major capacity shortfall. Could access to US and European expertise and quality training improve capacity and prevent the next pandemic? When new and deadly strains of influenza appear, their […]
SGE’s revolutionary electronic syringe provides critical performance when and where it is needed in demanding QA field applications. Introducing a new method or product into the world of compliance- and quality-conscious life science laboratories is a challenge. While ultimately appreciative of most technologies that will increase their quality and productivity, these laboratories insist first of […]
A Look at Protein Binding and Enzyme Assay Classes Overview Review accuracy and precision Discuss common liquid handler QC methods Artel MVS technology description Brief review of determining baseline liquid handler performance Discuss two case studies examining the effect of LH variability on assay performance: protein binding and enzyme activity
Automated liquid handlers have enabled dramatic improvements in the efficiency of screening the efficacy of potential new drug candidates, but just like a map they need to be calibrated against a universal ‘compass’.
This poster presentation describes the software system used to automate equipment performance investigations and improve monitoring of equipment. The system was designed to combine data from a variety of data sources with workflow specific logic to create a valuable data warehouse from which query and reporting tools provide actionable information about equipment performance.