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ATS-100 Acoustic Transfer System calibration using Artel MVS and DMSO Range E dye: A practical approach to developing calibration curves

By Scheibe, D., Palan, J., Khovananth, K.

Takeda California uses the non-contact ATS-100 Acoustic Transfer System in various compound management liquid handling activities in support of drug discovery processes. It is widely accepted that proper quality assurance is important for accurate and efficient processes – and proper calibration of automated liquid handling instruments is a key component of such quality assurance.

Poster

Pipetting Comparison of DMSO Versus Aqueous Solutions as Measured Using Dual-Dye Technology

By Parshley, R., Bradshaw, J., Albert, K.

This poster examines the differences in liquid delivery by automated liquid handlers dispensing both aqueous and DMSO-based test solutions. For the study discussed herein, an ALH was first optimized to dispense aqueous test solutions, after which these optimized aqueous method(s) were used to dispense identical target volumes of both DMSO- and aqueous-based MVS Sample Solutions into microtiter plates, which were then measured with the MVS to determine actual delivered volume.

Poster

Accuracy and Precision in Low Volume Liquid Transfers

By Tam, S., Rodrigues, G. - Artel, Forbush, M. - EDC Biosystems

Acoustic transfer systems operate by ejecting a rapid fire stream of tiny discrete droplets, with each droplet adding a few nanoliters to the total aliquot. This makes the system digital, in the sense that volumes can be changed by adjusting the number of droplets.

Poster

DMSO Sample Solution for Liquid Handler Performance Verification

By Parshley, R.

Dimethyl sulfoxide (DMSO) has become one of the most important solvents used for high-throughput screening (HTS) and compound management applications due to its ability to readily dissolve a wide range of compounds. It is also the solvent of choice for the new breed of acoustic droplet ejection (ADE) liquid handling instruments, developed by companies such […]

Publication

Best Practices for Assessing Nanoliter Transfer Performance for Labcyte Echo Liquid Handlers

By Bradshaw, J., Albert, K. - Artel, Mock, M., Shieh, J. - Labcyte

Acoustic drop ejection (ADE) technology enables low- nanoliter transfers for high-throughput screening applications. Verifying the absolute transferred volume and the well-to-well reproducibility of the ADE liquid handler is important for quality control, but there are few methods available that can quickly and accurately interrogate dispensed volumes in this range.

Poster

Verifying Mosquito Nanoliter Liquid Dispensing

By Schenker, B., Albert, K., Knaide, T.

Assay-ready plates are becoming key to maximizing throughput and assay robustness for many HTS departments. These plates contain test compounds prepared at specific concentrations from library stocks ahead of time. DMSO is routinely used for compound dissolution, but its presence at concentrations above 1% can markedly affect assay performance.

Poster

Development of a 100% DMSO Sample Solution for Liquid Handler Performance Verification

By Parshley, R., Bradshaw, J., Rodrigues, G., Albert, K., Olson, K., Rumery, D.

DMSO (dimethyl sulfoxide) has become one of the most important solvents used for high-throughput screening (HTS) and compound management applications due to its ability to readily dissolve a wide range of compounds. It is also the solvent of choice for the new breed of acoustic droplet ejection (ADE) liquid handlers, developed by companies such as Labcyte and EDC Biosystems, which have revolutionized HTS and compound management.

Poster

Automation of Nanoliter Volume Transfers

By Fay, J., Williams, E., Mosser, S., Harrell, C., Calamari, A., Mullen, F., Harkins, T., Bednar, R.

Doing More With Less Introduction To facilitate the discovery and refinement of lead compounds, our laboratory known as the Facility for Automation and Screening Technology (FAST) serves as a site hub for processing DMSO solutions into custom assay ready plates for Basic Research project teams. FAST integrated an in-house developed Laboratory Information Management System (WP […]

Poster
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