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Improving Assay Performance Using a Process Optimization Approach

By Hentz, N., Avis, A.

This poster presents two major findings. First, how to study liquid handlers as part of a system within the context of the assay being optimized. Second, it was possible to further optimize the overall performance of the assay by not only optimizing the liquid handlers, but by choosing the correct liquid handler-reagent pairing.

Poster

Does weather affect pipetting? YES!

By Rodrigues, G., Avis, E., Price, A., Gerber, V.

This study uses a two factor design (temperature and humidity) to investigate volumetric performance (precision and trueness) at environmental conditions from 15 °C to 30 °C and 30% to 80% relative humidity. Nine environmental conditions were tested, the mid point, four corner cases and four edge cases. Replicate testing was performed at the mid point and corner cases.

Poster

Standardization of Tecan Freedom EVO liquid handling platforms using the QC Kit

By Albert, K., Rodrigues, G., Sullivan, T.

This tutorial presented by Artel and Tecan will discuss the importance of standardization of these critical laboratory tools and how to control the performance of Tecan® Freedom EVO® liquid handling platforms using the Tecan QC Kit. In addition, we will summarize the results of an in-depth study on the effects of environmental conditions on liquid handler performance. This tutorial will illustrate how you can be confident that 1 µL is really 1 µL regardless of where, when or with what liquid handler the volume was dispensed.

Presentation

Introducing New Technology for Liquid Handling Quality Assurance

By Gigante, B., Bradshaw, J.

Controlling and optimizing the liquid handling component of drug discovery and other life science laboratory processes can save valuable time and resources. This tutorial introduces new technology from Artel, enabling fast, in-process volume determination of any liquid or solid dispensed or stored in microplate wells. Accurate, reliable, and repeatable volume measurements are achieved by applying pressure to individual sealed wells, regardless of the shape of the well, type of plastic, or density of the contents.

Presentation
Liquid handling

Artel Lab Report eBook – your guide to liquid handling data quality

By Artel

When testing accuracy, precision and trueness of liquid handling instruments, how many data points should you test for each volume? Does pipetting technique impact data reproducibility and accuracy? How often should you calibrate your pipettes? Have you recently thought about your assays and how much variability in liquid handling they can tolerate? This eBook is intended to help users of pipettes and automated liquid handling systems find answers to questions just like these.

Lab Report

How Pressure-Based Microplate Volume Measurement Works

By Knaide, T.

This article was originally published in Lab Manager. Problem: In virtually all research processes in which analytes and reagents are mixed in microplates, precise information on the starting volume in each plate well is critical to the accuracy and success of the process, as well as the results derived from it. While effective tools for […]

Publication

Pressure-Based Volume Measurement Technology for In-Process Measurement of Microplate Contents

By Gigante, B., Schwedes, C. - STRATEC, Bradshaw, J. - Artel

Introduction Modern drug discovery and research labs are utilizing complex automation systems to assist in high throughput screening of novel drug candidates. A large portion of these laboratories are using ANSI-SBS-standard 96- and 384-well plates to achieve the necessary throughput. The volume of sample transferred into and out of these plates can be critical to […]

Poster
Effect of Liquid Handler Accuracy on Assay Perfromance

Effect of Liquid Handling Accuracy on Assay Performance

By Hentz, N., Knaide, T.

This study illustrates how optimization of both liquid-handling accuracy and precision is critical to assay performance. The study was designed to examine (1) liquid-handling performance and (2) the effect of liquid-handling variability on two types of in vitro biochemical assays by making small but deliberate changes to assay volume delivery. Specifically, protein binding (streptavidin) and […]

Publication
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