Integration of Liquid Handler Quality Control Into the HTS Daily Routine

By Ellinger, B., Hochreiner, A., Schork, S., Wilkinson, M. | Application Note

Abstract

This application note describes how the MVS® Multichannel Verification System can be used to assess the performance of the liquid handlers integrated into a PerkinElmer cell::explorer high throughput screening (HTS) system.

The MVS enables users to measure the performance of all six of the liquid handlers integrated into the cell::explorer system over the entire volume range of 10 nL to 350 µL and provides data that allows direct comparability of instrument performance.

Previous studies have shown that highly accurate and precise liquid handling is critical if the results of HTS experiments are to be reliable. However, liquid handlers are prone to variation and error and need to be verified using a standardized methodology. The need for a standardized verification method becomes increasingly important when multiple liquid handlers are used in the same experiment, or when procedures are transferred between instruments and/or locations.

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12A6278