DMSO Sample Solution for Liquid Handler Performance Verification
By Parshley, R. | Publication
Dimethyl sulfoxide (DMSO) has become one of the most important solvents used for high-throughput screening (HTS) and compound management applications due to its ability to readily dissolve a wide range of compounds. It is also the solvent of choice for the new breed of acoustic droplet ejection (ADE) liquid handling instruments, developed by companies such as Labcyte (Sunnyvale, CA) and EDC Biosystems (Fremont, CA), which have revolutionized HTS and compound management.
Because DMSO has very different physical properties than water, the liquid most commonly used for calibration and performance verification, it behaves differently when handled by air-displacement pipettors or acoustic droplet ejectors, creating the need for a solvent-specific volume verification method.
View as published in LABOonline, September issue, page 42