Webinar: Effect of Liquid Handling Quality Control on Biological Assay Performance

Nov 15, 2013

assay-developmentDr. Nathaniel Hentz recently presented a webinar on the effect of liquid handling quality control on biological assay performance, and he demonstrated how optimization of both liquid handling accuracy and precision is critical to assay performance.

The liquid handling component of overall assay variability is often underappreciated or ignored, yet can have a significant impact on the outcome. Determining the variability in results stemming from the assay itself requires assessing a combination of liquid handling, biological and random variability sources. Many laboratories rely on precision alone to estimate the quality of the liquid handling.

This webinar addressed the following:

  • Liquid handling performance
  • The effect of liquid handling variability on in vitro biochemical assays, including:
    • Protein binding and enzyme activity assays
    • Inhibitor potency comparisons
    • Assay performance characteristics such as Z-factor, signal-to-background and variability

Watch the Webinar Now


About the Presenter

Nathaniel Hentz, PhD

Nat-HentzDr. Nathaniel Hentz is the Associate Director of the BTEC Analytical Lab at North Carolina State University. Prior to this current role, Dr. Hentz served as an independent consultant working with Artel offering guidance on their efforts toward automated liquid handling quality control within high throughput screening laboratories.

Dr. Hentz’s tenure in the HTS industry includes nearly two years as Sr. Research Investigator at Bristol-Myers Squibb in Wallingford, CT where his team supported the fully automated screening systems within the Lead Discovery group.

Prior to BMS, Dr. Hentz enjoyed seven years at Eli Lilly RTP Laboratories in North Carolina. During his tenure at Lilly RTP, Dr. Hentz was responsible for Tier 1 ADMET screening in 2004 and led the New Technologies group.

Dr. Hentz received his Ph.D. in analytical chemistry from the University of Kentucky in 1996 and joined Lilly as a postdoctoral scientist the same year.